This page contains information, links and resources for prescribing of contraceptives.
When prescribing contraception, information should be given on all available methods taking into consideration medical eligibility. This should include contraceptive effectiveness (including factors that alter efficacy), non-contraceptive benefits, health risks, and side effects to allow an informed decision to be made on the most suitable choice.
All currently available long-acting reversible contraceptive (LARC) methods (intrauterine devices (IUD), the intrauterine system (IUS), injectable contraceptives and implants) are more cost effective than the combined oral contraceptive pill even at one year of use. They are also the most reliable method of contraception. IUDs, the IUS and implants are more cost effective than the injectable contraceptives. Please see NICE guidance CG30.
See SWISH (Somerset Wide Integrated Sexual Health Services) for local services throughout Somerset.
See the Faculty of Sexual and Reproductive Healthcare (FSRH) for guidance during a second COVID-19 wave and beyond.
Please expand the topics below for more information.
Health and Care Video Library – Sexual Health
Combined Hormonal Contraceptives
- FSRH Combined Hormonal Contraception Guideline suggests that the traditional 21/7 Combined Hormonal Contraception (CHC) regimen with a monthly withdrawal bleed confers no health benefit over other patterns of CHC use. In addition, symptoms associated with the hormone-free interval (HFI) can be problematic and ovarian activity during a 7-day HFI could risk escape ovulation (particularly with lower doses of Ethinylestradiol (EE) and if use is not perfect). ‘Tailored’ CHC regimens in which there are fewer (or no) HFI and/or shortened HFI can be safely used to avoid withdrawal bleeds and associated symptoms and theoretically reduce the risk of contraceptive failure. Suggested tailored regimens (using a monophasic EE CHC) are described in the document linked above. Women should be told about tailored regimens and given their choice of regimen based on their preference. Tailored CHC regimens can reduce the frequency of withdrawal bleeds and can reduce withdrawal symptoms associated with the HFI; however, unscheduled bleeding is common.
- Progestogen-only contraceptives offer a suitable alternative to combined hormonal contraceptives when oestrogens are contra-indicated.
- NB: Some progestogen-only contraceptive pills only have a 3 hour window, including Noriday® and Norgeston®.
- Desogestrel has a 12 hour window. First line oral progestogen-only choice on formulary – prescribe generically.
- Intra-uterine POP system, LARCs remain a cost-effective and reliable choice.
- The choice of emergency contraception should be made with the patient, taking additional factors into consideration (such as the UK Medical Eligibility Criteria, the patient’s preference, current medication, and timing of sexual intercourse). They should be advised about the efficacy, adverse effects, advantages, and disadvantages of each method.
- The copper coil (Cu-IUD) is the most effective emergency contraception method, it should be offered to all patients seeking emergency contraception unless contraindicated or unsuitable.
- Levonorgestrel 1500mcg tablet is available via PGD through many pharmacies across Somerset, free of charge to all patients under 25 years. Patients aged over 25 years should contact their GP. Levonorgestrol 1500mcg (as Upostelle) is the first-line oral preparation for patients presenting within 72 hours of unprotected sexual intercourse (UPSI) or contraceptive failure. DO NOT PRESCRIBE AS THE OTC PREPARATION: Levonelle One Step® (as over twice the cost of the prescription-only product.)
- Patients presenting between 72 hours and 120 hours may be offered the choice of ulipristal acetate or intrauterine device and the risks and benefits of each method should be discussed with the patient. Ulipristal is licensed for emergency contraception within 120 hours (5 days) after UPSI. Pregnancy should be excluded before ulipristal is taken. EllaOne is excluded from the MHRA alert affecting ulipristal for uterine fibroid treatment.
- Levonorgestrel remains the preferred emergency hormonal contraception option for breastfeeding parents. Please see the Breastfeeding Network and SPS Q&A. The Cu-IUD remains a suitable option.
- Please note that patients who have a BMI >26 or are greater than 70kg may require more than the standard 1.5mg dose of levonorgestrel. Consider double dose (3mg) or Cu-IUD or ulipristal. See FSRH Clinical Guideline: Emergency Contraception for more information.
- Women taking enzyme inducing medication may require further measures. EC providers should advise women using enzyme-inducing drugs that the effectiveness of ulipristal and levonorgestrel could be reduced. Women requiring EC who are using enzyme-inducing drugs should be offered a Cu-IUD if appropriate. A 3mg dose of levonorgestrel can be considered but women should be informed that the effectiveness of this regimen is unknown. A double-dose of ulipristal is not recommended. See FSRH Clinical Guideline: Emergency Contraception for more information.
- Although the use of ellaOne does not contraindicate the continued use of regular hormonal contraception, ellaOne may reduce its contraceptive action. Therefore, if a woman wishes to start or continue using hormonal contraception, she can do so after using ellaOne, however, she should be advised to use a reliable barrier method until the next menstrual period. See summary of product characteristics for full details.
Medicines which may alter the effectiveness of oral contraceptives
- The effectiveness of combined oral contraceptives, progestogen-only oral contraceptives, contraceptive patches, and vaginal rings can be considerably reduced by interaction with drugs that induce hepatic enzyme activity (e.g. carbamazepine, eslicarbazepine, modafinil, nelfinavir, nevirapine, oxcarbazepine, phenytoin, phenobarbital, primidone, ritonavir, St John’s Wort, topiramate, and, above all, rifabutin and rifampicin) during use and for 28 days after stopping. Women using enzyme-inducing drugs should be offered a reliable contraceptive method that is unaffected by enzyme-inducers. See UKMi Q&A for more information.
- Contraceptive hormones can affect serum levels of drugs such as lamotrigine with potential significant clinical side effects. Women taking lamotrigine should be advised that combined hormonal contraception may interact with lamotrigine; this could result in reduced seizure control or lamotrigine toxicity. The risks of using CHC could outweigh the benefits.
- Hormonal contraceptives and antibacterials that do not induce liver enzymes – Advice on interactions between combined hormonal contraceptives and antibacterials that do not induce liver enzymes has been updated to take into account the recommendations of the Faculty of Sexual and Reproductive Healthcare Clinical Guidance: Drug Interactions with Hormonal Contraception (January 2011). Additional contraceptive precautions are no longer necessary when antibacterials that do not induce liver enzymes are taken with combined oral contraceptives, (unless diarrhoea or vomiting occurs), contraceptive patches or vaginal rings. More information on enzyme inducing drugs can be found in the British National Formulary.
- Please note that the evidence is too limited to make a definite recommendation regarding the effectiveness of combined oral contraceptives after bariatric surgery. The FSHR GDG recommend that women who have had bariatric surgery should be advised of potential reduced effectiveness of COC and should consider a non-oral method of contraception.
- See ‘Emergency Contraception’ for more information on interactions with EHC.
Contraception in patients taking medication with teratogenic potential
FSRH (February 2018) and MHRA (May 2019) guidance
Females of childbearing potential should be advised to use highly effective contraception if they or their male partners are taking known teratogenic drugs or drugs with potential teratogenic effects. Highly effective contraception should be used both during treatment and for the recommended duration after discontinuation to avoid unintended pregnancy. Pregnancy testing should be performed before treatment initiation to exclude pregnancy and repeat testing may be required.
Methods of contraception considered to be ‘highly effective’ include the long-acting reversible contraceptives (LARC) copper intrauterine device (Cu-IUD), levonorgestrel intrauterine system (LNG-IUS) and progestogen-only implant (IMP), and male and female sterilisation. For more information see the FSRH CEU statement, MHRA drug safety update, and the UK teratogenic information service.
Valproate medicines must not be used in women of childbearing potential unless the Pregnancy Prevention Programme is in place. If you are involved in the care of female patients on valproate in the UK, see a reminder of actions required for this medicine.
Risk of Venous Thromboembolism
The European Medicines Agency (EMA) review in 2013 concluded that there was good evidence to suggest that the risk of VTE associated with different combined oral contraceptive (COCs) was influenced by progestogen type, with those COCs containing levonorgestrel, norethisterone or norgestimate having the lowest risk and drospirenone, desogestrel or gestodene having the highest risk.
Risk of VTE per 10,000 healthy women over one year:
- COC containing ethinylestradiol plus levonorgestrel, norgestimate or norethisterone: 5-7
- COC containing etonogestrel (ring) or norelgestromin (patch): 6-12
- COC containing ethinylestradiol plus gestodene, desogestrel or drospirenone: 9-12
However, the EMA noted that the benefits of combined hormonal contraceptive use generally outweighed the risk of venous thrombosis, which is low overall and is lower than the VTE risk associated with pregnancy and the postpartum period.